International Journal for Quality in Health Care Advance Access published online on August 22, 2005
International Journal for Quality in Health Care, doi:10.1093/intqhc/mzi066
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1 Pharmacy, Hôpital Robert Debré AP-HP, Paris, France
* To whom correspondence should be addressed. Objective. To quantify the type and frequency of drug administration errors to pediatric in-patients and to identify associated factors. Design. Prospective direct-observation study of drug administration errors from April 2002 to March 2003. Setting. Four clinical units in a pediatric teaching hospital. Study participants. Twelve observers accompanied nurses giving medications and witnessed the preparation and administration of all drugs to all patients on all weekday mornings. Intervention. None Main outcome measure. Discrepancies between physicians' orders and actual drug administration. Results. During the 1719 observed administrations to 336 patients by 485 nurses, 538 administration errors were detected, involving timing (36%), route (19%), dosage (15%), unordered drug (10%), or form (8% form). These errors occurred for 467 (27%) of the 1719 administrations. Intravenous drugs (OR = 0.28; CI = 0.16-0.49; versus miscellaneous) were associated with fewer errors. Error rates were higher for cardiovascular (OR = 3.38; CI = 1.24-9.27; versus miscellaneous) and central nervous system drugs (OR = 2.65; CI = 1.06-6.59; versus miscellaneous); unspecified dispensing system (OR = 2.06; CI = 1.29-3.29; versus store in the unit); nonintravenous nonoral administration (OR = 4.44; CI = 1.81-10.88; versus oral administration); preparation by the pharmacy (OR = 1.66; CI = 1.10-2.51); and administration by a hospital pool nurse, temporary staffing agency nurse, or nurse intern (OR = 1.67; CI = 1.04-2.68; versus registered full-time nurse). Each additional management procedure in the patient increased the risk of error (OR = 1.22; CI = 1.01-1.48). Conclusions. The risk factors identified in our study should prove useful for designing preventive strategies, thereby improving the quality of care.
Accepted July 6, 2005
Article
Drug administration errors and their determinants in pediatric in-patients
2 Pharmacy, Hôpital Robert Debré AP-HP, Paris, France.
3 Public Health, Hôpital Robert Debré AP-HP, Paris, France
4 Neonatal Intensive Care Unit, Hôpital Robert Debré AP-HP, Paris, France
5 Nephrology Unit, Hôpital Robert Debré AP-HP, Paris, France
6 Intensive Care Unit, Hôpital Robert Debré AP-HP, Paris, France
7 General Paediatrics Unit, Hôpital Robert Debré AP-HP, Paris, France
Jean Eudes Fontan, E-mail: jean-eudes.fontan{at}jvr.ap-hop-paris.fr
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